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The contribution of the swallowed fraction of an inhaled dose of salmeterol to its systemic effects were analysed in a randomized, double-blind, crossover study. Colorful toy necklaces and bracelets, glow sticks, sparkly crowns and glittery butterfly wings worn by rave goers are all the rage, in part because they intensify the effect of the drugs, for example, albuterol and salmeterol. Table 2. Plasma corticosterone and normalized thymus weight in mice from Experiment 3. Both variables were significantly affected by corticosterone replacement but not antidepressant treatment see ANOVA results, below ; . Different superscripts denote significant differences by post-hoc testing between replacement groups. n 5-8 per group. The United States' National Institutes of Health, Division of AIDS officially approved the first two sites for the SMART Study CTN 190 ; in October, giving the green light for the start of recruitment for this major clinical trial. The first sites to win approval are at Victoria General Hospital in Halifax Drs. David Haase and Walter Schlech ; and Windsor Regional Hospital Dr. Jeff Cohen ; . A number of CTN investigators attended meetings of the SMART trial at the CPCRA meetings in Washington, D.C., Nov. 6-9. Dr. John Ruedy has agreed to stay on as Chair of the Scientific Review Committee until the next face-to-face meeting on May 10, 2005, in Vancouver. Dr. John MacLeod of Montreal has been sitting in for Dr. Marina Klein, who has been away on maternity leave. With at least one seat to fill, the Committee is now considering new candidates. If you are interested, please contact Dr. Don Zarowny, Programme Head Scientific and Industrial Liaison ; , at don hivnet.ubc . continued on page 2, because tiotropium salmeterol.

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Monotherapy comparison six studies ; : there was a significantly greater change in favour of salmeterol in morning pef and fev there were no significant differences in quality of life, exacerbations, or symptoms. Fig. 1. 2-Adrenoceptor -arrestin 2 complementation -galactosidase activity ; and cAMP accumulation stimulated by isoprenaline in C2C12 cells expressing the human 2-adrenoceptor galand -arrestin 2 galfusion proteins. a, -galactosidase activity [in relative light units RLU ; ] obtained in a single experiment after 1-h incubation with agonist in native C2C12 cells or C2C12 cells expressing the 2-adrenoceptor and -arrestin 2 fusion proteins. Similar data were obtained in five native C2C12 cells ; or nine fusion protein-containing cells ; separate experiments. Data points are mean S.E.M. of triplicate determinations. b, -galactosidase activity in C2C12 cells expressing the human 2-adrenoceptor galand -arrestin 2 galfusion proteins in response to isoprenaline and forskolin. Data are the mean values S.E.M. of four separate experiments. In each experiment, determinations were made in triplicate. c, cyclic AMP accumulation in response to isoprenaline in native C2C12 cells or in C2C12 cells expressing the human 2-adrenoceptor galand -arrestin 2 galfusion proteins. Values are mean S.E.M. of six replicates in a single experiment. Similar data were obtained in three C2C12 cells ; or four fusion protein-containing cells ; separate experiments. cAMP was measured using the DiscoverX assay as described under Materials and Methods. In the cells expressing the 2-adrenoceptor and -arrestin 2 fusion proteins, parallel studies were made of the effect of isoprenaline on the cAMP activity in the absence of the DiscovereX cAMP antibody and cAMP ED reagents. This background galactosidase activity contributed less than 6000 RLU to the overall signal and was not influenced by agonist concentration. d, effect of isoprenaline and salmeterol on cAMP accumulation DiscoverX ; in CHO-K1 cells transiently transfected with the human 2-adrenoceptor galfusion protein. Data are expressed as a percentage of the response to 3 M forskolin measured in each individual experiment ; . Values are mean S.E.M. of 16 isoprenaline ; and 18 salmeterol ; separate experiments and fluticasone.
Websites for you to check out: bbc northernireland blas Mabh N Mhuir and Lynette Fay discuss the issues of the day in the Irish language magazine programme Monday - Thursday 7.30pm on BBC Radio Ulster ist le BLAS Luan go Dardaoin 7.30pm beo ar BBC Raidi Uladh 92-94.5FM 1341MW gaelachas Irish Primary & Post-Primary Schools & Summer Colleges in Cork Ireland pobail.ie Website of the Department of Community, Rural and Gaeltacht Affairs may.ie language vifax NUI Maynooth online learning for those who wish to learn Irish. Bairbre.uitheighneain mhb.ie If you would like to be on the mailing list for the Midland Health Board Course in Beginners' Irish. Injectable ergogenic drugs or use of such drugs by sexual partners Male homosexuality and girls with bisexual partners What is the best way to handle clearance decisions? Studies show that 3.1%-13.9% of athletes require further evaluation before a final clearance status can be determined. The initial clearance for an athlete can be divided into 4 categories and advil, for instance, salmeterol inhaler. The swelling pressure of Kollidon CL in water is about twice as high as that of the micronized product, Kollidon CL-M. The ideal particle size with the highest swelling pressure is the Kollidon CL fraction of 106 125 m [391]. In nonpolar solvents such as cyclohexane, hexane, dioxane and ethyl acetate, crospovidone hardly swells at all. Even in acetone it swells much less than in water, as can be seen from Fig. 48. In 0.1 N hydrochloric acid too, it swells significantly less than in isotonic salt solution [221]. Fig. 49 shows how the volume of Kollidon CL increases with time when it swells. These results were also obtained with tablets produced with a compression force of only 1.5 kN, and their increase in volume was measured against time when they were exposed to water on one side only. If the tablets were exposed to water on all sides, swelling would set in somewhat earlier. It is interesting to note that a similar swelling volume was measured for Kollidon CL-M, even though the swelling pressure it develops is much lower.
Throughout our stay there, we felt that we had accomplished something memorable and had forged priceless relationships and friendships. The emotional impact was mutually received by both the Vietnamese and the team. We had learnt so much of Vietnam, its culture and its people, and had felt an affinity to them. After the expedition, the majority of youths felt that their views on life had changed to a certain extent. They learnt to value their families, parents and homeland of Singapore so much more. As the youths missed the comforts of home, they talked openly of what they would do when we all reached home. It is surprising that the conversation that we had did not move along the lines of what kinds of food we would devour although that did come up later ; , but how we would greet our loved ones upon our return to Singapore. Some of the youths said that they would hug their parents and tell them that they love them something that they would have never done otherwise ; . They learnt to appreciate each other more because of the companionship and affinity we all shared throughout the expedition. The youths learnt to deal with adversity, diversity and the change in environment as well. They learnt to live each day without the conveniences they had previously taken for granted. In this respect, we were exposed to a new culture, a new way of life and the simple hospitality of the Vietnamese people. Living on the grounds of the CEES proved to be a fortunate thing as we had the chance to interact with other students of our host community. The youths are looking forward to sharing their learning experience with GraceHaven Children's Home on 27 Dec 2003 and hope to inspire the GraceHaven's youths to join a guided Youth Expedition Project in the future." construction of a pavement for one of the local primary schools that we visited. All in all, I believe that the library will help the children to fuel their interest for learning and the quest for knowledge. The pavement will make life more comfortable for the school children, especially on days when it is raining, making the grounds all muddy and slippery. This trip has really benefited me quite a lot, giving me knowledge about myself and learning new skills like carpentry and guitarplaying, which I had lots of fun mastering during the time when we were resting in our rooms. I managed to learn some simple Vietnamese words and accepted their local food here, with the plaintasting vegetables and tough chicken. Most of all, through the events and unexpected incidents that we have experienced as a team, I've learnt two important essences of life- "give and take" and "forgive and forget and theophylline.
Francis, S. H., Lincoln, T. M., and Corbin, J. D. 1980 ; J. Biol. Chem. 255, 620-626 Wilkinson, A. J., Fersht, A. R., Blow, D. M., and Winter, G. 1983 ; Biochemistry 22, 3581-3586 Andrews, P. R., Craik, D. J., and Martin, J. L. 1984 ; J. Med. Chem. 27, 1648-1657 Zoraghi, R., Francis, S.H., Wood, D., Bischoff, E., Hutter, J., Knorr, A., Niedbala, M., Enyedy, I., Pomerantz, K., and Corbin, J.D. 2005 ; Int. J. Impot. Res. In Press Corbin, J. D., Turko, I. V., Beasley, A., and Francis, S. H. 2000 ; Eur. J. Biochem. 267, 2760-2767 Mullershausen, F., Friebe, A., Feil, R., Thompson, W. J., Hofmann, F., and Koesling, D. 2003 ; J. Cell Biol. 160, 719-727 Rybalkin, S. D., Rybalkina, I. G., Shimizu-Albergine, M., Tang, X. B., and Beavo, J. 2003 ; EMBO J. 22, 469-478 Blount, M. A., Beasley, A., Zoraghi, R., Sekhar, K. R., Bessay, E. P., Francis, S. H., and Corbin, J. D. 2004 ; Mol. Pharmacol. 66, 144-152 Thomas, M. K., Francis, S. H., and Corbin, J. D. 1990 ; J. Biol. Chem. 265, 14964-14970 Turko, I. V., Francis, S. H., and Corbin, J. D. 1998 ; J. Biol. Chem. 273, 6460-6466.

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1. Transdermal form of 17bE Estraderm ; developed by Novartis. This compound significantly improves cognitive functions in women at menopause. 2. Synthetic analogues of 17aE, such as agents J811 and J861 developed by JenaPharm. These drugs display a strong anti-oxidant activity in experiments in vitro in this connection they were named ``scavestrogens'' ; , 137 and an ability to stimulate cognitive functions on a neurotoxicological animal model of AD.138 Neuroprotective properties of these compounds are probably not associated with their effect on transcription processes. 3. A number of newly synthesised conjugated estrogens that display stronger anti-oxidant properties than 17bE.139 and albenza.

He following poster presentations have been prepared for the Academy of Managed Care Pharmacy 2002 Educational Conference, October 912, in Washington D.C. For more information about the studies described below, please contact the corresponding authors, indicated by an asterisk * ; , whose addresses are listed in full. The names of individuals who are scheduled to present at the meeting are underlined. Abstracts were edited by Merle Fossen, PharmD, RPh.
And other respiratory-related, were higher for salmeterol than for formoterol patients over a six-month fo11ow-up period. LEARNING OBJECTIVES: Audience participants will: 1. Learn how daily costs vary over time for patients taking formoterol and albendazole. The main conclusion of this first large-scale, randomised, double-blind trial was that more deaths occurred with salmeterol but, compared with salbutamol, this difference was not statistically significant. Safety of short acting beta2-agonists Regular terbutaline use has no adverse effects on the clinical response to inhaled corticosteroids in mild to moderate asthma, although sputum eosinophil counts increased with terbutaline treatment alone, consistent with some previous studies 1 ; . Increased allergen-induced mast cell degranulation is seen after 10-day regular monotherapy with salbutamol 2 ; , emphasizing again that regular short acting beta2-agonist monotherapy cannot be recommended in atopic asthma. Furthermore, PEF reduction during regular monotherapy with salbutamol seems to be genetically influenced 3 ; . Differential effects of enantiomers isomers ; of beta-agonists Purified enantiomer-selective products of salbutamol are now commercially available, and similar products of other beta2-agonists are in development. Bronchodilator action resides in the R enantiomer. Advantages to using products containing only the R enantiomer have been proposed, but the clinical relevance is unclear 4 ; . Effect of changing from CFC to HFA propellants Most of the current short and long acting beta2-agonist bronchodilators are or will soon be available in HFA preparations. There is no evidence that the new propellant significantly changes key aspects of the pharmacokinetics or pharmacodynamics of beta-agonist action, although individual products show differing properties such as spray speed and less dose-to-dose variability 5 ; . Impact of long acting beta-agonists on response to short acting beta-agonists When studied under laboratory conditions, regular treatment with long acting beta-agonists can produce short acting beta-agonist subsensitivity, an effect partially prevented by a bolus dose of high dose inhaled or systemic corticosteroid 6 ; . Low doses of inhaled corticosteroids may not be as effective at preventing this effect. A subsensitivity effect is evident in the Formoterol And Corticosteroids Establishing Therapy FACET ; study's run-in period, but was not evident in smaller studies 7 ; . However, large scale clinical trials indicate that there is continued adequate bronchodilator response to short acting beta-agonists, despite regular, twice-daily use of long acting beta-agonists, including during episodes of acute asthma 8, 9 ; . Comparison of salmeterol and formoterol efficacy and safety Neither salmeterol nor formoterol has been shown to have major adverse effects in patients with asthma when used in conjunction with inhaled corticosteroids. Airway responsiveness is not increased after six months of therapy with formoterol 8 ; . New data have confirmed the ability of salmeterol to reduce inhaled corticosteroid doses 10 ; , consistent with previous data for both salmeterol and formoterol. These two compounds cannot be regarded as interchangeable: the greater and spironolactone.

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Several clinical situations, different classes of antiasthma drugs may be combined to achieve optimal asthma control. Such combination regimens can be complex, with the potential for misuse. A new product now on the market as Advair or Seretide combines the inhaled corticosteroid fluticasone propionate with the long-acting -adrenergic bronchodilator salmeterol in a single Diskus inhaler. The goal is to improve disease control by addressing both the inflammatory and bronchoconstrictive components of asthma. The author reviews available evidence regarding the use of combined therapy, focusing on the Advair Diskus device. Current guidelines for asthma management emphasize a stepwise approach, starting with low-dose inhaled corticosteroids and adding other medications as needed for disease control, including long-term control medications. Inhaled corticosteroid therapy is essential.

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1. Ampicilline In Capsules, Injections Etc 2. Ibuprofen With Or Without Paracetamol Or Other Compounds 3. Amoxycyllin In Capsules, Injections Etc. 4.Penicillin In Capsules, Injections Etc 5. Amclos In Capsules Injections Etc. 1. Salbutamol, Terbutaline, Ephedrine, Salmetrrol And Methyl Xanthimes 2. Rifampicin 3. Heamatinics And Erythropoietin 4. Ibuprofen With Or Without Paracetamol Or Other Compounds 5. Amoxycyllin In Capsules, Injections Etc. 1. Amoxycyllin In Capsules, Injections Etc. 2. Tranquilizers 3. Penicillin In Capsules, Injections 4. Heamatinics And Erythropoietin 5. Chlormphenicol Capsules, Injections Etc and glimepiride.

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Wu, A.W., et al., Quality of care and outcomes of adults with asthma treated by specialists and generalists in managed care. Arch Intern Med, 2001. 161 21 ; : p. 2554-60. Use of Appropriate Medications for People with Asthma. , in The State of Managed Care Quality. 2004, National Committee for Quality Assurance. Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med, 2000. 343 15 ; : p. 1054-63. Hoekstra, M.O., et al., Eosinophil and mast cell parameters in children with stable moderate asthma. Pediatr Allergy Immunol, 1998. 9 3 ; : 143-9. Jonasson, G., K. Carlsen, and P. Blomqvist, Clinical efficacy of low-dose inhaled budesonide once or twice daily in children with mild asthma not previously treated with steroids Eur Respir J 1998. 12 5 ; : 1099104. Simons, F.E., A comparison of beclomethasone, salmeterol, and placebo in children with asthma. Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group. N Engl J Med, 1997. 337 23 ; : p. 1659-65. van Essen-Zandvliet, E.E., et al., Effects of 22 months of treatment with inhaled corticosteroids and or beta-2-agonists on lung function, airway responsiveness, and symptoms in children with asthma. The Dutch Chronic Non-specific Lung Disease Study Group. Rev Respir Dis, 1992. 146 3 ; : p. 547-54. Adams, N., J. Bestall, and P.W. Jones, Budesonide for chronic asthma in children and adults. Cochrane Database Syst Rev, 2001 4 ; : p. CD003274. Adams, N., J. Bestall, and P.W. Jones, Inhaled fluticasone propionate for chronic asthma. Cochrane Database Syst Rev, 2001 3 ; : p. CD003135. Adams, N.P., et al., Inhaled beclomethasone versus placebo for chronic asthma. Cochrane Database Syst Rev, 2005 1 ; : p. CD002738. Banov, C.H., W.C. Howland, 3rd, and W.R. Lumry, Once-daily budesonide via Turbuhaler improves symptoms in adults with persistent asthma. Ann Allergy Asthma Immunol, 2001. 86 6 ; : 627-32. Bronsky, E., et al., Comparative clinical study of inhaled beclomethasone dipropionate and triamcinolone acetonide in persistent asthma. Ann Allergy Asthma Immunol, 1998. 80 4 ; : 295-302. Kemp, J., et al., Rapid onset of control with budesonide Turbuhaler in patients with mild-to-moderate asthma. Ann Allergy Asthma Immunol, 1999. 82 5 ; : 463-71. McFadden, E.R., et al., Administration of budesonide once daily by means of turbuhaler to subjects with stable asthma. J Allergy Clin Immunol, 1999. 104 1 ; : p. 46-52. Miyamoto, T., et al., A double-blind, placebo-controlled dose-response study with budesonide Turbuhaler in Japanese asthma patients. Japanese Pulmicort Turbuhaler study group. Respirology, 2000. 5 3 ; : 24756. O'Byrne, P.M., et al., Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial. J Respir Crit Care Med, 2001. 164 8 Pt 1 ; 1392-7. Pauwels, R.A., et al., Early intervention with budesonide in mild persistent asthma: a randomised, doubleblind trial. Lancet, 2003. 361 9363 ; : p. 1071-6. Wolfe, J.D., et al., Effectiveness of fluticasone propionate in patients with moderate asthma: a doseranging study. Clin Ther, 1996. 18 4 ; : 635-46. Busse, W., et al., Low-dose fluticasone propionate compared with montelukast for first-line treatment of persistent asthma: a randomized clinical trial. J Allergy Clin Immunol, 2001. 107 3 ; : p. 461-8. Israel, E., et al., Effects of montelukast and beclomethasone on airway function and asthma control. J Allergy Clin Immunol, 2002. 110 6 ; : p. 847-54. Nathan, R.A., E.R. Bleecker, and C. Kalberg, A comparison of short-term treatment with inhaled fluticasone propionate and zafirlukast for patients with persistent asthma. J Med, 2001. 111 3 ; : p. 195202. Riccioni, G., et al., Effectiveness of montelukast versus budesonide on quality of life and bronchial reactivity in subjects with mild-persistent asthma. Int J Immunopathol Pharmacol, 2002. 15 2 ; : 149-155. Riccioni, G., et al., Comparison of montelukast and budesonide on bronchial reactivity in subjects with mild-moderate persistent asthma. Pulm Pharmacol Ther, 2003. 16 2 ; : 111-4. Baumgartner, R.A., et al., Distribution of therapeutic response in asthma control between oral montelukast and inhaled beclomethasone. Eur Respir J, 2003. 21 1 ; : 123-8. Brabson, J.H., et al., Efficacy and safety of low-dose fluticasone propionate compared with zafirlukast in patients with persistent asthma. J Med, 2002. 113 1 ; : p. 15-21.
In adolescents and adults, no evidence of an additional benefit is available for the administration of saljeterol fluticasone in a fixed combination inhaler compared with the administration of salmterol and fluticasone in separate inhalers or vice versa ; regarding patient-relevant therapy goals. In fact, when applying the same inhaling system Diskus ; , the trials on salmteerol and fluticasone also provide similar results for fixed combination inhalers and separate inhalers and anacin.
Advair has recently fallen under scrutiny due to studies connecting advair's salmeterol component to an increased risk of respiratory death.

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Is PHI trying to bypass physicians as gatekeepers to a person's health? and panadol and salmeterol, for example, salmeterol discus. Assessments Activities to be completed prior to preparing medications ; 7. 8. 9. Check medication card or MAR against physician's orders or medication kardex, according to facility policy. Check for the SIX RIGHTS. Review your knowledge of medications and look up needed information such as drug actions, therapeutic effects, side effects, usual doses routes, contraindications and nursing implications. Review resident data and observe and assess residents on an on-going basis to determine therapeutic effects, side effects, drug allergies, contraindications, and nursing implications.

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Both autopsy findings and other clinical indicators of health Conwell, Forbes, Cox, & Caine, 1993; Pannelee, Thuras, Katz & Lawton, 1995 ; . The Lndex of Co-Existent Disease was developed for use in a study which demonstrated ageism in the treanent of and acetaminophen.

Sites that score below 90% but higher then 70%, will be notified of a random follow-up visit which will be completed within six 6 ; months of the initial visit. If an office fails to meet the 70% requirement, they will be notified by the Health Plan of the areas that were deficient and required to submit a corrective action plan. The Credentialing Committee will grant the practitioner's approval for acceptance to the Health Plan network on a probationary status following the approval of the corrective action plan. The Health Plan will re-audit or evaluate the appropriate documentation as identified in the corrective plan following sufficient time for implementation of corrective actions to ensure the corrective action plan has been satisfied. Should the office not fully satisfy the corrective action plan, the Health Plan will continue to work with the office to develop the required elements to satisfy the Health Plan. 3-9 yr girl with chronic asthma p w asthma not responding to inhaled bronchodilators has been given oral steriod it looks like an a c attack, so irrespecive of what she is having, give nebulised brronchodilators 4-4 yr old with eczema & mild wheeze has night cough not respondint to inhale dbronchodilators twice night inhaled long actingg steroid, salmeterol is the doc for nocturnal wheeze. Pharmacy benefits for their employees. By this stage, many purchasers were beginning to realize that one key to diminishing overall health care costs was.

Likelihood of stone passage than those not given such treatment pooled risk ratio 1.65; 95% CI 1.45-1.88 ; . The pooled risk ratio for alpha blockers was 1.54 1.29-1.85 ; and for calcium-channel blockers with steroids was 1.90 1.51-2.40 ; . InfoPOEMs: The limited amount of available data suggest that alpha blockers and calcium channel blockers appear to speed the passage of kidney stones. Furthermore, it appears that combining these medications with steroids provides additional benefit. LOE 1a, for example, salmeterol onset.

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Group of 130 men `members' ; and their families of the `Sinaga' ethnicity living in the locality of Depok, approximately 600 persons. The group is divided into several geographic sector groups. Monthly premium: IDR10, 000. Group of all Batak men and their families living in the same vicinity, regardless of their subgroup memberships. 3 senior members are Ketua of 3 existing subgroups. 3 Ketua form the executive council, which meets once every 3 months. One of the Ketua is the legal account holder of the Arisan's bank account. They hold this office for a two-year renewable term. Products: Premium IDR1, 000 month if they encounter deficits then collection of additional contributions ; Benefits: inpatient health coverage lump sum IDR100, 000; education benefits Group activities: group members are involved in many social activities as well as welfare activities such as vocational training household economics Premiums are distributed as follows: 50% held by the group for benefits, the reserve, 30% `self' as savings ; , 10% for the Bishop, and 10% for national level-association and fluticasone. Believe they may ultimately be shown to have implications for type 2 diabetes as well. We will look for similar extension studies to UKPDS and certainly at the very least, hope that interest in tight glycemic control and reaching A1C targets will continue to intensify. * * * From Diabetes Close Up, many great wishes to you and yours for 2006! Diabetes Close Up is a newsletter highlighting notable information and events in the diabetes industry. This newsletter is put forth as an unbiased commentary on the industry and is not meant to serve as a recommendation to buy or sell or hold! ; any stocks. Companies in which Close Concerns writers have stock and or that are current or past clients of Close Concerns include Abbott, Animas, Amylin, DiObex, Johnson & Johnson, Medtronic, Metrika, Roche, and Sanofi-Aventis. If you have any suggestions or comments regarding content, please contact info closeconcerns . If you would like to subscribe to DCU, please contact subscribe closeconcerns . If you would like to offer any suggestions or comments regarding content, please contact info closeconcerns . More information and disclosures found on our website closeconcerns. ADDITIONAL DISCLOSURES Rodman & Renshaw, LLC. the "Firm" ; is a member of NASD and SIPC and a registered U.S. Broker-Dealer. ANALYST CERTIFICATION: I, Elemer Piros, hereby certify that the views expressed in this research report accurately reflect my personal views about the subject company ies ; and its their ; securities. As of June 30, 2007, neither the Firm nor its affiliates beneficially own 1% or more of any class of common equity securities of THE RATED COMPANIES MENTIONED IN THE REPORT. Neither the research analysts nor the Firm has any material conflict of interest with THE RATED COMPANIES MENTIONED IN THE REPORT, of which the research analysts know or have reason to know at the time of publication of this research report. The research analyst principally responsible for preparation of the report does not receive compensation that is based upon any specific investment banking services or transaction but is compensated based on factors including total revenue and profitability of the Firm, a substantial portion of which is derived from investment banking services. Except for Neurobiological Technologies and Neurochem, the Firm or its affiliates did not receive compensation from THE RATED COMPANIES MENTIONED IN THE REPORT for any investment banking services within twelve months but intends to seek compensation from THE RATED COMPANIES MENTIONED IN THE REPORT for investment banking services within three months, following publication of the research report. Neither the research analysts nor any member of the research analysts' household nor the Firm serves as an officer, director or advisory board member of THE RATED COMPANIES MENTIONED IN THE REPORT. Except for AVANIR Pharmaceuticals, Cortex Pharmaceuticals, CytRx Corp., Genentech, Medivation, Memory Pharmaceuticals, Myriad Genetics, Nastech Pharmaceuticals, Neurobiological Technologies, Neurochem, Prana Biotechnology Ltd., and Repligen Corp., the Firm does not make a market in the securities of THE RATED COMPANIES MENTIONED IN THE REPORT as of the date of this research report. Any opinions expressed herein are statements of our judgment as of the date of publication and are subject to change without notice. Reproduction without written permission is prohibited. The closing prices of securities mentioned in this report are as of August 1, 2007. Additional information is available to clients upon written request. For complete research reports on THE RATED COMPANIES MENTIONED IN THE REPORT, please call 212 ; 356-0500. Readers are advised that this analysis report is issued solely for informational purposes and is not to be construed as an offer to sell or the solicitation of an offer to buy. The information contained herein is based on sources, which we believe to be reliable, but is not guaranteed by us as being accurate and does not purport to be a complete statement or summary of the available data. Past performance is no guarantee of future results.

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P1227 Efficacy and safety of the new beclomethasone dipropionate formoterol combination vs. fluticasone propionate salmeterol pMDIs in moderate to severe persistent asthma Pierluigi Paggiaro 1 , Alberto Papi 2 , Yuri I. Feschenko 3 , Gabriele Nicolini 4 , Leonardo M. Fabbri 5 . 1 Cardio-Thoracic Department, Respiratory Pathophysiology, Pisa, Italy; 2 Research Centre on Asthma and COPD, University of Ferrara, Ferrara, Italy; 3 Pulmunology Department, Academy of Medical Science of Ukraine, Kiev, Ukraine; 4 Medical Department, Chiesi Farmaceutici, Parma, Italy; 5 Section of Respiratory Diseases, University of Modena, Modena, Italy Background: The recommended treatment for moderate to severe asthma is the combination of an inhaled corticosteroid ICS ; and a long acting beta 2 agonist. Aim: In this study we compared the newly developed combination of beclomethasone and formoterol with Chiesi ModuliteTM HFA pMDI technology, with the marketed combination of fluticasone and salmeterol MDI. Methods: This was a phase III, multinational, multicentre, double-blind, doublemasked, randomised, two-arm parallel groups, controlled study. After a 2-week run-in period on low dose ICS, patients with moderate to severe asthma were randomised to a 12-week treatment period on beclomethasone 200 mcg plus formoterol 12 mcg bid or fluticasone 250 mcg plus salmeterol 50 mcg bid. Results: 227 patients were evaluable for ITT. A significant improvement from baseline in lung function, symptoms and rescue medication use was observed in both groups at any time point p 0, 001, NS between groups ; . The analysis of non-inferiority on primary endpoint showed no difference between groups in last 2-week morning PEF adjusted means 329.6 L min vs 333.0 L min; difference 3.32; 95%CI -17.92, 11.28 ; . No significant difference was shown in number of patients with exacerbations, adverse events, effects on heart rate and ECG QTc ; . No significant difference from baseline and between groups was shown in 12h overnight urinary cortisol creatinine. Conclusions: The newly developed Chiesi ModuliteTM combination of beclomethasone plus formoterol is equivalent to the marketed combination of fluticasone and salmeterol in terms of efficacy and safety.

In 2003 a black box warning was added to product packaging for drugs that contain salmeterol, including serevent inhalation aerosol, serevent diskus, and advair diskus. Intervention Long-acting theophylline 10-15 g mL ; Short-acting metaproterenol 2 day ; Long-acting theophylline 12.3 2.9 g mL ; Short-acting salbutamol 200 g - 4 day ; Long-acting theophylline Short-acting albuterol 200 g-4 day ; Long-acting theophylline 12.3 3.4 g mL ; Short-acting salbutamol 200 g-4 day ; Short-acting theophylline 12-18 g mL ; Short-acting albuterol 2 180 g ; Long-acting theophylline 10-15 g mL ; Short-acting salbutamol 200 g-4 day ; Long-acting theophylline 10 g mL ; Short-acting salbutamol 2 200 g ; Long-acting theophylline 10-20 g mL ; Long-acting salmeterol 42 g.

We chose to study the salmeterol fluticasone propionate combination rather than salmeterol alone because combination treatment has been shown clinically to have greater effects than monotherapy in patients with copd and salmeterol has been considered to be effective clinically because of its bronchodilator rather than antiinflammatory effects.

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