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To ASA was 16% in the zileuton group, 11% in the cysleukotriene receptor antagonist group, and 15% in the control group. For patients with aspirin-exacerbated respiratory disease, cys-leukotriene receptor antagonist therapy appears to reduce the rate of lower respiratory tract reactions while increasing the rate of upper airway reactions. This shift in target organ responses is not accompanied by any change in the percentage of false-negative challenges in patients taking LTMDs. Patients taking LTMDs as controller medication should continue to take these drugs when undergoing oral ASA challenges. COMMENT: The effect of LTMDs on ASA-induced asthma and rhinitis reactions has been a confusing area since these agents were introduced several years ago. Although it was clear early on that LTMDs failed to prevent these reactions completely in most cases, the Scripps Clinic ASA challenge data base has provided more detailed observations. It appears that the LTMDs attenuate the reactions by selectively reducing the lower airway response, thereby shifting some patients to an isolated upper airway response. S. A. T. Berges-Gimeno MP, Simon RA, Stevenson DD: The effect of leukotriene-modifier drugs on aspirin-induced asthma and rhinitis reactions. Clin Exp Allergy 32: 1491-1496, 2002.
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Increased invasive behavior of HIF-1 deficient astrocytomas in the brain cannot be attributed solely to loss of VEGF but implies other factors. Taken together, these results demonstrate that HIF-1 has differential roles in tumor progression, which are greatly dependent on the extant microenvironment of the tumor. Further, our observations support the notion that anti-VEGF treatment is a favorable strategy but that inhibition of HIF-1 thereby impairing the hypoxic response might not be a desirable strategy to treat astrocytomas, as they appear to adapt by becoming more invasive and infiltrative. AN-30. EXPRESSION OF SPHINGOSINE-1-PHOSPHATE RECEPTORS REGULATING PROLIFERATION AND INVASION IN GLIOBLASTOMAS James R. Van Brocklyn, * Catherine Jackson, * Dennis K. Pearl, * and Nicholas Young#; * Department of Pathology, * Department of Statistics, and #Integrated Biomedical Science Graduate Program, The Ohio State University, Columbus, OH, USA Sphingosine-1-phosphate S1P ; , a bioactive lipid present at high levels in brain tissue, signals through G protein-coupled receptors to regulate proliferation and migration of a wide variety of cells. We have investigated the effects of S1P on human glioma cells. S1P potently stimulates proliferation and motility invasiveness of approximately 50% of human glioblastoma cell lines. Interestingly, glioblastoma cells that respond mitogenically to S1P do not necessarily show enhanced motility, nor do those that migrate in response to S1P necessarily also show enhanced proliferation. Glioblastoma cell lines that respond mitogenically to S1P express higher levels of the S1P receptor S1P1 than cells that do not respond, while cell lines that show enhanced motility in response to S1P express relatively low levels of S1P2, which is known to prevent S1P-induced cell motility. Preliminary data from real-time quantitative PCR analysis of RNA isolated from human glioma tissue revealed that a subpopulation of glioblastomas express higher levels of S1P1, but not S1P2 or S1P3, in comparison to low-grade gliomas. S1P1 has been shown to stimulate cell motility in several cell lines. Thus, glioblastomas express higher levels of the S1P receptor that correlates with a mitogenic and motility response to S1P, S1P1, and relatively low levels of the receptor that is known to prevent S1P-induced motility, S1P2. Stimulation of motility by S1P was chemokinetic rather than chemotactic, suggesting that autocrine signaling by S1P could enhance invasiveness of glioma cells in vivo. Consistent with this possibility, human glioblastoma cells were found to secrete S1P extracellularly. Thus, S1P may play important roles in the pathobiology of these highly malignant tumors. This study was supported by grant #R01 NS41517 from NINDS.
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Achieving sustained remission; in fact, the efficacy of psychotherapy for PD rivals that of medications. During CBT, the best-studied psychotherapy for controlling panic attacks, patients are taught to tolerate the bodily sensations they experience.47 Early intervention after the patient reports having his or her first panic attack can be critical. One study of the efficacy of a single-session prevention program for PD was conducted at University of California, Los Angeles, Student Health Services. Individuals who had reported having a single panic attack but had not yet been diagnosed with PD were randomized either to be treated in a 5-hour workshop or to be put on a waiting list. At the 6-month follow-up visit, only 1.8% of workshop participants had developed PD, compared to 13.6% of the wait-list control group.48 Other efficacious treatments include in vivo exposure homework exercises to be completed by the patient. The primary care provider should encourage the patient to undertake various activities eg, to get the patient out of the house, suggest attempting feared activities in a gradual and safe manner, and doing exercises to practice measured breathing ; , read self-help guides, and attend support groups, for example, ibuprofen.
20. ACE AND GENDER DE: PENDENT IMPACT OF CHll, DHOOD OBESITY ON BLOOD PRESSURE Qing f-Ic', %ong Yi Ding?, I ; aniel Yee Tak Pang', Johan Karlberg', 1. Dcpartmcnt of I'acdiatrics, Queen Mary Hospital, The University of Ilong Kong, Hong Kong'; Beiling f'ediatric Kcsearch Institute, Beijing `hlldrcn's tlospital, China'; and the Clinical Trials Ccntrc. t: aculty of Medicine, The liniversity of Ilong Kong, hong Kong' Obesity is associated with olevntcd blood prcssurc fjP ; both in adults and children. Childhood obesity has become a sevcrc health problem cspccially during the last fc`ccb dcc; ~dcs. So far there has not been any propcr and Inrgcscalt' study spcciticatly focusing on the association bctwccn obesity and [ I' in arty lift. The aim of the present study was to systematically examine the association between obesity and BP in preschool Chincsc children in mainland China. Specifically weight. height and BP values wcrc collected from a nationwide case-contra I study of 748 boys and 574 girls aged from 0. I to 6.9 years in 8 cities in mainland China undcrtakcn In 1996. One obosc child and one non-obese child wcrc matched for gender- and age. The mean BP diffiircnccs between the obese and control groups ivcre 6.0 mm t Ig for syctolic and 4.6 tnn Hg for diastolic P c 0.05 ; bct\veen 3.0 and 6.9 years of: fol both gcndcrs. The elevated BP was positively correlated with the BMI value of the child P c 0.05 ; . For younger children 0.1 2.9 years ; only girls showed a significant differcncc P : 0.05 ; in the mean E3Pbetween the cases and the controls. Based on this large population based case-control study, during the lirst seven years of life. we conclude that obesity is clearly associated with an elevated systolic and diastolic BP. The association was howcc w not so distinct clwing the first three years of life indicating that childhood obesity. rnthcr than infant obesity. may hnvc a more profound in tlucncz on or association with BP.
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