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Centres, including hospital dermatology and vascular medicine departments, and private practices. Dermatologists and angiologists phlebologists took part. Subjects were adult, non-immunosuppressed patients presenting with a non-infected, non-malignant leg ulcer of predominantly venous origin ABPI 0.8 ; . Ulcers were between 4cm2 and 40cm2 in size, with granulation tissue covering more than 50% of their surface area. Ulcer duration ranged from three to 18 months. Patients were followed-up by the investigating physician for eight weeks on a weekly basis; this included clinical examination, wound area tracings and photographs. Nurses hospital or visiting ; assessed exudate volume and clinical appearance at dressing changes. RESULTS: Ninety-one patients were included: 47 in the Urgotul group and 44 in the DuoDERM E group. Baseline patient demographic data and wound characteristics were comparable in the two groups. After eight weeks of treatment wound surface area had reduced by a mean of 61.3% in the Urgotul group and 52.1% in the DuoDERM E group NS dressings were changed more frequently in the DuoDERM E group 2.54 + - 0.57 times per week versus 2.31 + - 0.45 in the Urgotul group, p 0.047 ; . Thirty-three local adverse events were recorded in 27 patients: 10 in the Urgotul group and 23 in the DuoDERM E group p 0.039 ; . Nurses reported better acceptability for the Urgotul dressing, based on pain on removal, maceration and odour p 0.0001 ; . CONCLUSION: Both dressings showed similar efficacy for the local treatment of venous leg ulcers. Nevertheless, medical and nursing staff reported better tolerance and acceptability for the Urgotul dressing. Publication Types: Clinical Trial Clinical Trial, Phase IV Comparative Study Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't PMID: 16048220 [PubMed - indexed for MEDLINE] 13: Burns. 2005 Nov; 31 7 ; : 890-3. Epub 2005 Jul 14. Biobrane versus duoderm for the treatment of intermediate thickness burns in children: a prospective, randomized trial. Cassidy C, St Peter SD, Lacey S, Beery M, Ward-Smith P, Sharp RJ, Ostlie DJ. Department of Pediatric Surgery, The Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA. In this study, we directly compared the efficacy of Biobrane and Duoderm for the treatment of small intermediate thickness burns in children in a prospective, randomized fashion to determine their relative impact on wound healing, pain scores, and cost. Patients under 18 years of age with intermediate thickness burns on a surface area less than 10% were enrolled and treated with one of the two dressing systems. Data collected included mechanism of injury, time to complete healing, pain scores, and institutional cost of materials until healing was complete. No significant difference in time to healing or pain scores was detected between the two groups. The cost of each treatment was statistically more expensive in the Biobrane group. The results of this study demonstrate that Duoderm and Biobrane provide equally effective treatment of partial thickness burns among in the pediatric population. However, Duoderm is statistically less expensive than Biobrane and can be considered a first-line treatment option for intermediate thickness burn wounds in children. Publication Types and
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ABSTRACTS - ORAL PRESENTATIONS SATURDAY ; 025 THE IMPACT OF NOCTURNAL HEMODIALYSIS ON QUALITY OF LIFE: RESULTS OF A RANDOMIZED CLINICAL TRIAL. B Manns1, 2, S. Klarenbach2, 3, M Walsh1, R. Quinn1, M Tonelli2, 3, N Scott-Douglas1, 2, G Mortis1, 2, H. Lee1, BF Culleton1, 2. 1. Department of Medicine, University of Calgary, Calgary, Alberta; 2. Alberta Kidney Disease Network, Alberta; 3. University of Alberta, Edmonton, Alberta. Observational studies suggest that nocturnal hemodialysis NHD ; improves quality of life. Prior to widespread uptake of this therapy, data from randomized trials are required. We did a randomized trial in 52 HD patients, comparing NHD with conventional thrice weekly hemodialysis CvHD ; over 6 months. Change in health-related quality of life HRQOL ; from baseline to six months, measured with EQ-5D index scores range 0-1 ; , was a main secondary outcome. HRQOL was measured at randomization before treatment allocation was known ; , at baseline time that entry visit occurred and training initiated for NHD group ; , and at study end 6 months ; . HRQOL data was available for 48 patients at study end. Results are displayed below ; : Difference in QOL Change in EQ-5D Index EQ-5D score over time Intention to Treat ; score and escitalopram.
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ACKNOWLEDGMENTS This paper is in part based on the synopsis of presentations and discussions that took place at the Featured Topic session on spectrum of alveolar epithelial ion channels, Experimental Biology 2004 Meeting, Washington, DC, April, 2004. The authors appreciate the excellent presentations of their findings by the speakers Drs. L. Bankir, T. DeCoursey, C. Ehrhardt, J. Fang, and K. Muellertz ; and lively discussions from the participants at the Featured Topic session. Present address of P. J. Kemp: Cardiff School of Biosciences, Cardiff University, Biomedical Sciences Bldg., Museum Ave., PO Box 911, Cardiff CF10 3US, Wales, UK E-mail: KempPJ Cardiff.ac ; . GRANTS The authors thank the following agencies for continued support: National Heart, Lung, and Blood Institute Grants HL-38658 and HL-64365 ; , Wellcome Trust, British Heart Foundation, and Hastings Foundation. AJP-Lung Cell Mol Physiol VOL.
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10-minute period. Subsequent work by Johnston and colleagues28 demonstrated that the minimum dysrhythmic dose of epinephrine injected into the submucosa of the mouth and or nose was about 2 g kg for halothane, 3.5 g kg for enflurane Ethrane, Anaquest ; and 5.5 g kg for isoflurane Forane, Anaquest ; . When 0.5 percent lidocaine was injected with 1: 200, 000 epinephrine, the minimum dysrhythmic dose during halothane anesthesia increased to 3 g because of the lidocaine's cardioprotective effect. Thiopental Pentothal, Abbott Laboratories ; , an ultrashort-acting barbiturate, also is capable of enhancing the dysrhythmogenic potential of adrenergic drugs. This fact was not appreciated in previous studies involving halothane, 27, 28 as thiopental often was used for induction of anesthesia, and has led to the revised dosage guideline of 1 g epinephrine if halothane is used with thiopental and 2 g kg epinephrine if it is used alone.29 Although the mechanism by which general anesthetics augment the dysrhythmic actions of adrenergic agents is unknown, it appears to involve the simultaneous stimulation of both 1 and receptors.30, 31 Epinephrine and levonordefrin each are capable of activating both receptor types and eliciting dysrhythmias during general anesthesia. However, phenylephrine NeoSynephrine, Sanofi-Winthrop ; , a selective 1 agonist, and isoproterenol Isuprel, SanofiWinthrop ; , a agonist, similarly disrupt the cardiac rhythm only if given together. As shown in Table 2, this "established" interaction warrants a 1 rating. The dentist treating.
In addition to the differences between the seeds of the "species" noted above, there seem to be consistent differences between wild and cultivated seeds of each type. Wild seeds tend to be smaller, with comparatively well-developed abscission zones, narrow bases, and a papery layer perianth ; of marbled or mottled appearance. Germination is slow and irregular. All these characteristics are thought to be of survival value in nature. Wild plants will often have minimal energy for seed production, making numerous small seeds an obvious selective advantage. Likewise, the narrow bases and well-developed abscission zones help to facilitate dispersal, while the marbled coat might provide protection or camouflage against seed eaters. Slow, erratic germination will be desirable where water availability may be irregular, particularly during the first months of the growing season. Many, if not most, wild populations have only recently escaped from cultivation. They show the above characteristics to varying degrees, influenced by the continual escape of drug and fiber strains to interbreed with them. It should be pointed out, however, that there is also considerable variation among seeds of both cultivated and wild strains, A recent study found that wild populations in southern Asia, especially India, were largely lacking the marbled perianth, while most wild Chinese seeds were rather large and had no adhering perianth or base elongation-thus resembling the cultivated seeds. Many cultivated seeds have the marbled perianth, but it usually sloughs off easily and seldom persists on the mature seed. One generalization which can be made about marijuana seeds is that they can survive for extremely long periods if conditions are right. And there are a variety of "right" conditionsOne Japanese scientist found high germination rates in seeds kept dry with calcium chloride for 14 years. Another American ; study of fiber type hemp seeds found that low temperatures were the most important factor: better than 95% of seeds kept for eight years, stored in cloth bags or sealed jars, germinated when the temperature was maintained at 10 * C less. Seeds kept in a freezer maintain viability quite well, because diamicron dosage.
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The four types of programs with the number of programs that DATOS studied in parentheses were outpatient methadone 29 ; , outpatient drug-free 32 ; , long-term residential 21 ; , and short-term inpatient 14 ; . Three of the four types were also studied in DATOS's two predecessors: the Drug Abuse Reporting Program DARP ; , which included admissions to treatment from 1969 to 1973, and the Treatment Outcome Prospective Study TOPS ; , which and
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Commission and correct responses were not distinguished. The lack of a significant SessionResponse interaction suggested that both erroneous responses and correct responses contributed to this effect. However, inspection of Table 2 demonstrates that there was no substantial increase in the CRN, whereas there was an increase in Ne ERN. Consistent with the findings of Mathalon et al. 2002 ; and Alain et al. 2002 ; , we did not find any abnormalities in Pe or amplitude in the schizophrenic participants. There are two main limitations of this study. The first is that because acutely ill patients are difficult to recruit for ERP studies and more likely to decide not to finish a longitudinal study, there was a relatively small sample size. Although the correlational findings discussed below are of interest because of their relevance to previous research, the small sample size as well as the exploratory nature of the correlation analysis must be kept in mind. The second limitation is that the healthy volunteers only participated in a single ERP session. Therefore, some caution should particularly be taken in interpreting the comparisons of the healthy group with the patients at time 2. Although we have no reason to believe that there may be an instability in Ne ERN, Pe, CRN or Pc amplitudes in healthy people over time, it remains a possibility. Holroyd and Coles 2002 ; have suggested that the Ne ERN is generated when anterior cingulate cortex neurons are disinhibited by a temporary reduction in inhibitory signaling from the mesencephalic dopamine system. This led them to predict that Ne ERN amplitude would be abnormal in Parkinson's disease, in which the mesencephalic dopamine system is underactive. However, they found that the Ne ERN was not abnormal in patients with Parkinson's disease following overnight withdrawal of dopamine enhancing medication Holroyd et al., 2002 ; . In contrast, Falkenstein et al. 2001 ; observed a reduction in Ne ERN amplitude in patients with Parkinson's disease receiving dopamine enhancing treatment. Together, these findings support the hypothesis that the Ne ERN is related to dopaminergic function, but suggests that a reduction in Ne ERN amplitude occurs when there is an increase in dopamine transmission relative to an underlying deficit in baseline dopaminergic transmission. Although there is little support for the hypothesis that dopaminergic hyperactivity is the central abnormality in schizophrenia, there is nonetheless substantial evidence that dopamine neurotransmission is abnormal e.g. Laruelle et al., 1996 ; , particularly in the anterior cingulate Benes et al., 2000; Suhara et al., 2002 ; . The precise nature of this abnormality remains uncertain. One plausible hypothesis is that acute schizophrenia is associated with phasic dopaminergic overactivity occurring against a background of reduced tonic dopaminergic activity Grace, 1991, 1993; Abi-Dargham et al., 2000.
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