Participants Twenty-two premenopausal women, free of sexual complaints, were enrolled in this study which consisted of two sessions. Six of the 22 women were excluded from the study after their first session for the following reasons: did not start an OCP n 3 stopped OCP use due to medical reasons n 1 and did not return telephone calls to schedule the second session n 2 ; . Therefore, we present data from 16 participants. We recruited women via advertisements posted campus-wide at the University of British Columbia and in local newspapers. All women were planning to take a self-selected OCP in the near future and were involved in a heterosexual relationship. Exclusion criteria were assessed during an initial telephone screen and included a ; age less than 18 years and older than 30 years, b ; non-heterosexuality, c ; use of medications known to affect sexual functioning e.g., antihyperten.
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They remain in office for a period of not more than three financial years, established at the time of their appointment and fall from office on the date of the meeting called for approval of the balance sheet relating to the last financial year of their office. The directors can be re-elected, fall from office and are replaced in accordance with the law. Art. 21 Whenever, due to resignations or for other reasons the majority of the directors fall from office, the entire board is deemed to have fallen from office; the meeting for the appointment of all the directors must be urgently called by the board of auditors, which may in the meantime carry out the actions of ordinary administration. Art. 22 The board elects the chairman from among its members; it may also elect a vice chairman and a secretary, also on a permanent basis, who may not necessarily be a member of the board. Art. 23 The board of directors meets either at the registered office or elsewhere provided it is in Italy, in other countries belonging to the European Union, or in the United States of America whenever the chairman deems necessary or whenever a written request to do so made by at least two of its members. Art. 24 The meeting is convened by the chairman by letter to be dispatched at least eight days before the meeting to each directors and statutory auditor and, in cases of urgency, by telegram, electronic mail message with confirmation of receipt, or by fax to be dispatched at least two days beforehand. Even whenever they are not convened as above, the meetings of the board of directors are deemed to be validly constituted whenever all the directors in office and all the statutory auditors are present. The meetings of the board of directors may also be held by video or audio conference on condition that each of the participants can be identified by all the others and that each of the participants is able to take part in real time during the discussion of the matters examined, and to receive, transmit and examine documents. Whenever these conditions exist, the meeting is deemed to be held wherever the chairman and the secretary are present. Art. 25 To be deemed valid, the resolutions passed by the board require the effective presence of the majority of its members in office. The resolutions are passed with the absolute majority of the votes of those present. The board resolutions must be recorded in minutes signed by the chairman and the secretary of the meeting. Art. 26 The directors are entitled to reimbursement of any expenses incurred while carrying out their official duties. The meeting may also assign the board an annual allowance and
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Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein. Schroeter H, Williams RJ, Matin R, Iversen L, Rice-Evans CA. Wolfson Centre for Age-Related Diseases, Guy's, King's, and St. Thomas's School of Biomedical Sciences, King's College, Guy's Campus, London, England. Free Radic Biol Med 2000 Dec 15; 29 12 ; : 1222-33 Oxidative stress is implicated in neuronal loss associated with neurodegeneration such as in Parkinson's disease, Alzheimer's disease and age-related cognitive decline. Recent reports indicate that the consumption of flavonoid-rich fruits partly reverses the age-related neuronal and cognitive decline. In this study, cultured striatal neurons were exposed to oxidized lipids in the form of lowdensity lipoprotein oxLDL ; as a model for the induction of oxidative injury, and the abilities of phenolic antioxidants, flavonoids and hydroxycinnamic acid derivatives, to attenuate this neuronal damage were examined. OxLDL was demonstrated to enter neuronal cells and to be capable of eliciting neurotoxicity in a dose- and time-dependent manner, inducing DNA fragmentation and cell lysis. Flavonoids exert protective effects, which appear to be related to specific structural characteristics, particularly relevant being those defining their reduction potentials and partition coefficients. In summary, these data suggest a possible role for flavonoids in reducing neurodegeneration associated with chronic disorders in which oxidative stress is implicated. CSF-folate levels are decreased in late-onset AD patients. Serot JM, Christmann D, Dubost T, Bene MC, Faure GC. Laboratoire d'Immunologie, GRIP, JE DRED 251, Faculte de Medecine, UHP, Nancy, France. faure grip.u-nancy J Neural Transm 2001; 108 1 ; : 93-9 Folates are involved in the cerebral metabolism of cobalamine, methionine, Ltyrosine and acetylcholine. Remarkably CSF-folate levels are 3 to 4 times higher than blood-folate levels. To reach the brain, folates are actively transported by choroid plexus CP ; as well as vitamins B6, B12, C and E. Epithelial atrophy having been reported in aging and in Alzheimer's disease AD ; , we measured the CSF folate-levels of 126 patients, including 30 AD consecutive patients to evaluate whether CP functions of folate-transport were impaired. CSF-folate concentrations did not vary with age 10.47 + - 1.93ng ml between 20 and 60 years; 9.96 + - 2.01 ng ml in elderly control patients older than 60 years of age, p 0.05 ; while late-onset AD patients had significantly lower CSF-folate levels 8.26 + - 1.82 ng ml, p 0.001 ; . These data support a specific alteration of CP transport function in AD patients. The pathogenesis of Alzheimer's disease.
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Management of persistent pain in older persons. J Geriatr Soc 2002; 50 6 Suppl ; : S20524. Sanders S, Harden N, Benson SE, Vincente PJ. Clinical Practice Guidelines for chronic nonmalignant pain syndrome patients II: an evidencebased approach. J Back Musculoskel Rehabil 1999; 13: 4758. American Pain Society. Principles of analgesic use in the treatment of acute pain and cancer pain. 4th ed. Glenview IL ; : American Pain Society; 1999. Guidelines for the initial evaluation of the adult patient with acute musculoskeletal symptoms. American College of Rheumatology Ad Hoc Committee on Clinical Guidelines. Arthritis Rheum 1996; 39: 1 Practice guidelines for chronic pain management. A report by the American Society of Anesthesiologists Task Force on Pain Management, Chronic Pain Section. Anesthesiology 1997; 86: 9951004. Gore DR, Sepic SB, Gardner GM. Roentgenographic findings of the cervical spine in asymptomatic people. Spine 1986; 11: 52124. Boden SD, McCowin PR, Davis DO, Dina TS, Mark AS, Weisel S. Abnormal magnetic resonance scans of the cervical spine in asymptomatic subjects: a prospective investigation. J Bone Joint Surg 1990; 72: 1178 Stiell IG, Wells GA, Vandemheen KL, et al. The Canadian c-spine rule for radiography in alert and stable trauma patients. JAMA 2001; 286: 1841 Hoffman JR, Mower WR, Wolfson AB, Todd KH, Zucker MI. Validity of a set of clinical criteria to rule out injury to the cervical spine in patients with blunt trauma. N Engl J Med 2000; 343: 94 Keats TE, Dalinka MK, Alazraki N, et al. Cervical spine trauma. American College of Radiology. ACR appropriateness criteria. Radiology 2000; 215 Suppl: 243 6. Seidenwurm D, Drayer BP, Anderson RE, Braffman B, Davis PC, Deck MD. Myelopathy. American College of Radiology appropriateness criteria. Radiology 2000; 215 Suppl: 495505. Fry SW, Seeff LB. Hepatotoxicity of analgesics and anti-inflammatory agents. Gastroenterol Clin North 1995; 24: 875905. Garcia-Rodriguez LA, Hernandez-Diaz S. The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents. Arthritis Res 2001; 3: 98 Deyo RA. Drug therapy for back pain: which drugs help which patients? Spine 1996; 24: 2840 Browning R, Jackson JL, O'Malley PG. Cyclobenza0rine and back pain: a meta-analysis. Arch Intern Med 2001; 161: 161320. Garvey TA, Marks MF, Weisel SW. A prospective randomized double-blind evaluation of trigger point.
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