Introduction: "Plasmin" Everpride Pharmaceutical ; is a commercially available health food supplement that contains an earthworm extract. Preliminary studies suggested that it might have fibrinolytic properties. We therefore tested its efficacy and safety in a randomised, double-blind, placebo-controlled trial. Method: 30 normal healthy men participated with informed consent and were randomised to either Plasmin 750 mg three times daily or matching placebo capsules for 28 days. Blood samples were taken at 1, 2, 7, and 28 days for haematological and biochemical tests. Results: There were no significance changes in blood count, renal function, liver function, blood glucose, and lipid profile. There was a small difference 1.04s 0.31, p 0.002 ; in the activated partial thromboplastin time APTT ; between Plasmin and placebo. There was no incidence of abnormal bleeding. The number of adverse events AEs ; in the 2 treatment groups 9 AEs in 4 placebo-treated subjects and 7 AEs in 3 Plasmin-treated subjects ; was comparable. None of the adverse events were related to trial medication. Plasmin was well tolerated by the subjects. Conclusions: Plasmin is a safe and well-tolerated Chinese medicine. In this short-term study, we have not found any adverse haematological effects. A large clinical trial of long duration is needed to evaluate its efficacy in the prevention of thromboembolic diseases!
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The origins of restricting drugs to sale in pharmacies dates back hundreds of years. For instance, in Germany between the 14th and 18th centuries pharmacists were given exclusive rights to market drugs and other products such as sugar, spices, liquors, wine, tobacco, coffee, and chocolate in order to ensure a livelihood to pharmacists. Over time, the exclusive rights to sell products became increasingly limited to medicines. However, the rationale for these restrictions remained the same: to protect the pharmacies on behalf of the public welfare. In the 17th century, apothecaries were given exclusive right to sell medicines in Britain. See Sonnedecker, 1976. ; More information on current drug classification systems is in appendix III.
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