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Souls' to the children". A student says: "I love the openness, If I have to complain about something I'm not afraid the teacher will revenge or punish me". In the case of the ICT-based innovations, this intimacy affects people's attitudes different ways: in one hand, it generates social pressure, by which teachers decide to join the innovation; but in the other hand, in a milieu where everyone knows everyone, "ICT offers a wider territorial space to act" a teacher ; . The educational continuum allows the learning of skills and working methods from grade 1 onwards. For example, students acquire ICT skills from grade 1 while learning the regular curricular subjects. There are no special ICT lessons. They also learn from other students' work, as a teacher put it "There is an added value when young students use their elder brothers friends' Website's materials as consumers, and in the upper grades they become also producers. When students see the connection between the Website, the research in the field and the school activities - they can realize in their minds the scope and the depth of a topic and their role in relation to it". The distance from the central part of the country encourages ICT use. As the computer coordinator stated, it is because of its distance from the center of the country that the school encourages high achievements and does not want to be seen as a small school in the far countryside. For this reason ICT is considered an essential educational means allowing the students, for example, to reach experts all over the country, to take part in international competitions, or to collaborate with students in the Jordanian village of Rah'me in the salt flat project. The principal, who holds a PhD in Geology and is a lover of trips and nature, visited the village and made the contacts for cooperation in the areas of education and tourism. The cooperation begun to flourish, but due to the events in the region it was suspended. Thanks to such kinds of projects, the principal succeed in recruiting valuable resources for supporting the schools development. Staff development concerning ICT and the innovation The school's policy and nationally defined goals are interrelated in harmonic manner. The school is committed both to excellency and academic achievements, and to national goals such as to settle the Aravva area, to flourish the desert, and to establish peaceful bonds with the Jordanian neighbors. "It was exciting for us to realize that we are going to be part of a national project, related to the Peace process" computer coordinator, regarding the salt flat project with Jordanian students ; . After 10 years of ICT use in school, it is perceived as an obvious tool contributing to the individual student as well as to the whole school system. All teachers received basic training in ICT skills, but since the last year each one advances according to her or his needs. Many teachers feel that they want to get a good perception of the technology, without dealing with technicalities, "I'm not interested in learning programming nor html, but I want to get the general idea and spirit of things. I think we have succeeded in assimilating the computer as everyday tool, like a typewriter, a mail box, or a personal folder". The computer coordinator adds "in a different situation I would have never been involved in such initiatives, looking all the time for updates in the technology". Not all teachers are equally competent in using ICT. 25% are directly involved in the Websites development, another 35% store there materials they prepare for their lessons. The other teachers are not involved with ICT, and about 10% even oppose to its use in school. "Give me free access to the University library and I will get for you materials in a tenth of the time you spend on the Internet. I would like people to remember what the computer really is: a Golem. And what is important is the human in front of it" a not involved teacher ; . Team work among teachers has significantly increased: "the computer represents for us a very convenient playing field for collaboration". The creation of subjects such as "Culture" obliged teachers to share the development of teaching and assessment materials, and they found ICT a valuable means for "working on each other files, reflect on them, and come ready to the meetings". Leadership of the innovation and ICT The principal and his team lead the innovation. The principal sees himself as peer to the teachers. He conceives management as a matter of leading team work towards common goals rather than as a matter of authority. Authority and respect result from his personal acquaintance with the students by election he teaches many hours a week to maintain personal contact with them ; and personal example. Also to.
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IS PHARMACOKINETICS OF STIRIPENTOL LINEAR? E. Rey, PharmD, V. Jullien, PharmD, P. D'Athis, PhD, J. Vincent, PharmD, G. Pons, MD, PhD, Hopital Saint Vincent de Paul, Centre Universitaire de Dijon, Biocodex, Paris, France. BACKGROUND: Stiripentol STP ; is an antiepileptic drug which efficacy has been demonstrated in severe myoclonic epilepsy and strongly suggested in partial epilepsy as an add-on therapy. A pharmacokinetic PK ; study was performed in healthy volunteers as the linearity of STP PK remains controversial. METHODS: A randomised double blind cross-over study at 3 different single oral doses 500, 1000, 2000 mg as tablets ; was performed in 12 subjects. Sixteen blood samples were collected in each subject. STP plasma concentrations were determined by HPLC. Data were analysed using a compartmental analysis. RESULTS: A two-compartment model with a zero order absorption R0 ; and a significant lag-time fitted the data. The following parameters were calculated : Cmax 3.1 0.9, 7.1 mg l ; , R0 356 194, 742 mg h ; , Cl F 58 28, 33 l h ; , AUC 0-inf 9.3 3.4, 33.1 mg.h l ; and T1 2 4.4 2.1, h ; after the 500, 1000 and 2000 mg dosages respectively. Dose-normalized Log10 AUC ; were found significantly different p 10 ANOVA ; between groups. However the half-life was not significantly different between the 1000 and the 2000 mg dosage. CONCLUSION: A dose-dependent non-linear STP PK can be concluded, probably due to an increase in bioavailability , possibly a saturable first-pass effect. However stable concentrations are expected at steady-state as the elimination phase is linear first order and
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